High-temperature method for the production of ribavirin.

摘要

A method for the production of a 1,2,4-triazole nucleoside comprising the step of reacting a ribose donor with a triazole compound in the presence of an enzyme preparation derived from Brevibacterium acetylicum is disclosed. The method is characterized in that the ribose donor is guanosine and the temperature during at least a part of the reaction is at or above 65 DEG C. The method is capable of high production rates and high concentrations of the final product.