| 摘要 |
New substituted 1H-imidazoles and their salts, processes for the preparation thereof and pharmaceutical compositions. These compounds have the formula <IMAGE> wherein R1, R2, R3 and R5=hydrogen or C1-C4-alkyl; R4=hydrogen, C1-C4-alkyl or C1-C4-alkoxy; Y1=hydrogen and Y2=OZ2 or the reverse; Z1=Z2=hydrogen or C1-C4-alkyl or Z1 and Z2=-CH2- or -C(CH3)2-. These compounds are prepared either by reducing a corresponding imidazole compound having a hydroxyl or alkoxy group on the methyl bridge between the imidazole and phenyl rings, or by hydrolyzing a 4-[[2,2-dimethyl-4H-1,3-benzodioxin-6(or 8)-yl]methyl]-1H-imidazole, or yet by reducing an alkyl 3-[(1H-imidazol-4-yl)methyl]-2-hydroxybenzoate. These compounds have cardiac, cerebral and tissular anti-ischemic activities.
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