| 摘要 |
A hermetic multi-barrier tamperproof package for encasing articles such as pharmaceutical products and the like, is disclosed. The package comprises: a first container typically being made of a substantially impervious plastic material into which the articles to be protected are placed prior to hermetically sealing the container so as to enclose the articles, and so as to further enclose normal atmosphere air within the container. A second container typically being made of a substantially impervious plastic material completely encloses the first container. The first and second containers are simultaneously separated from and connected to one another by attaching means comprising one or a number of discs having appertures in their centers, so as to allow a hermetic cavity defined between the first and second containers to extend continuously therebetween. A sensor comprising a select chemical or material is inserted within the cavity, and a select atmosphere such as a substantially evacuated atmosphere is simultaneously introduced within the cavity. The sensor and the select atmosphere co-operatively comprise a package integrity indicating sensor system where the sensor is simultaneously reactive to normal atmosphere air, and reversibly responsive to the presence or absence of the select atmosphere. A breach in package integrity will result in a loss of the select atmosphere and in exposure of the sensor to the normal atmosphere air enclosed within the first container and/or to the exterior atmosphere, whereby a chemical or physical response will occur that will produce an indication appealing to the sense of sight, touch, or smell at the point of puncture, or within the cavity that could evidence a package tampering. At least the first container incorporates sealingly associated cap and body portions being provided with recloseable closure means. Alternatively, the select atmosphere is omitted and the sensor is sandwiched between and in contact with the outer surface of the first container and the inner surface of the second container. One or more barriers can be completely enclosing the second container, and at least one cavity can exist between the first container and an outermost barrier.
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