发明名称 |
Transdermal multipolymer drug delivery system |
摘要 |
A dermal compositon comprising a drug, a multi-polymer of vinyl acetate, polyethylene and optionally one or more monomers, a natural or synthetic rubber and a tackifying agent. The ratio of the multipolymer to the rubber is, respectively, about 1:1 to about 10:1 and more preferably 1:1 to 5:1 and more preferably 3:1. The dermal composition can optionally contain a crosslinking agent, tackifiers, penetration enhancers and other ingredients known for use in adhesives for the transdermal delivery of drugs. The dermal compositions can be produced by a variety of methods known in the preparation of drug containing adhesive preparations including the homogenous mixing of the multi-polymer, drug and optional crosslinking agent and additional ingredients in aqueous solution followed by removal of excess water.
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申请公布号 |
US4814168(A) |
申请公布日期 |
1989.03.21 |
申请号 |
US19880164482 |
申请日期 |
1988.03.04 |
申请人 |
NOVEN PHARMACEUTICALS, INC. |
发明人 |
SABLOTSKY, STEVEN;QUESTEL, JOHN M.;LEESON, DOROTHY J. |
分类号 |
A61F13/02;A61K9/70;A61K31/21;A61K31/565;A61L15/16;A61L15/18;A61L15/44;A61L15/58;A61M37/00;(IPC1-7):A61K31/74 |
主分类号 |
A61F13/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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