发明名称 |
Transdermal laminated pharamaceutical compositions having prolonged effect and process for the preparation thereof |
摘要 |
The invention relates to a transdermal laminated pharmaceutical composition (plaster) having prolonged effect, wherein one or more storing layer(s) comprising the active ingredient, an ethylene/vinyl acetate copolymer regulating layer and an adhesive layer are applied onto the carrier. The pharmaceutical composition is prepared by coupling a carrier comprising the active ingredient with a regulating layer consisting of an ethylene/vinyl acetate copolymer foil having a vinal acetate content of 2-40 molar %. The foil is previously irradiated in a thickness of 100-300 mu m with a high-energy irradiation in a dose of 1-15 Mrad-preferably with electrone radiation-and thereafter stretched at 80 DEG -90 DEG C. to a thickness of 2-200 mu m. The system comprising the carrier and the regulating layer is subsequently coupled with an adhesive layer.
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申请公布号 |
US4814174(A) |
申请公布日期 |
1989.03.21 |
申请号 |
US19870101623 |
申请日期 |
1987.09.28 |
申请人 |
EGIS GYOGYSZERGYAR;MUANYAGIPARI KUTATO INTEZET |
发明人 |
BARTA, IREN;FEKETE, PAL;PALLOS, LASZLO;KOVACS, GABOR;MAHR, LAJOS |
分类号 |
A61K9/70;(IPC1-7):A61F13/02 |
主分类号 |
A61K9/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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