摘要 |
3-Amino-2-oxoazetidine-1-carboxamide derivs. of formula (I) or their salts are prepd. by reacting β-lactam of formula (II) with isocyanate of formula (III). In the formulas, R1 is acyl; R2 is H or methoxy; R3 and R4 are each H, alkyl, alkenyl, cycloalkyl, aryl, or 5,6 or 7 cyclic hetero ring; R5 is H, alkyl or aryl; R6 is H, alkyl, aryl, 5,6 or 7 cyclic hetero ring, -NR7R8 or (CH2)nX[n=1-4; x=halogen, aryl, alkoxy or aryloxy; R7=R8=H, alkyl or aryl . (I) and their salts are useful as antibacterial agents.
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