| 摘要 |
PURPOSE: To satisfactorily determine the lithium concentration of a liquid biological test sample by precipitating the lithium in the form of suspended particles by adding a lithium precipitating reagent to the liquid sample and measuring the intensity changing rate of transmitted or scattered light. CONSTITUTION: The lithium contained in a biological test sample, such as the blood serum, whole blood, blood plasma, urine, saliva, spinal fluid, etc., is precipitated in the form of suspended particles by adding a lithium precipitating reagent to the sample. The reagent is composed of an alkali transition metal periodate so that the lithium can form an insoluble complex at the time of precipitation. The resulted mixed solution of reaction is irradiated with a luminous flux and the intensity of the transmitted or scattered light is measured. The highest changing rate of the optical concentration is measured for a fixed period of time and a standard curve is prepared from the linear dosage response. The quantity of lithium contained in the liquid sample is measured from the standard curve. Since the highest changing rate of the optical concentration is measured, the lithium concentration of the liquid sample can be measured with high accuracy without removing lipids nor proteins from the sample.
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