发明名称 |
Thiadiazoles useful in the treatment of senile dementia. |
摘要 |
<p>A class of novel thiadiazoles, substituted on one of the ring carbon atoms with a non-aromatic azacyclic or azabicyclic ring system, and substituted on the other ring carbon atom with a substituent of low lipophilicity, or a hydrocarbon substituent; are potent muscarinic agonists, and have good CNS penetrability. The compounds are therefore useful in the treatment of neurological and mental illnesses, and are also of benefit in the treatment of severe painful conditions.</p> |
申请公布号 |
EP0307142(A1) |
申请公布日期 |
1989.03.15 |
申请号 |
EP19880308127 |
申请日期 |
1988.09.01 |
申请人 |
MERCK SHARP & DOHME LTD. |
发明人 |
BAKER, RAYMOND;SAUNDERS, JOHN;MACLEOD, ANGUS M.;MERCHANT, KEVIN |
分类号 |
A61K31/40;A61K31/425;A61K31/435;A61P25/00;A61P25/04;A61P25/28;C07D417/04;C07D453/02;C07D453/06;C07D471/08;C07D487/08 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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