Process for the preparation of 3,5-dioxo cyclohexane carboxylic acid derivatives.

摘要

A process for the preparation of a cyclohexane compound of the formula I. <CHEM> wherein R represents a hydrogen atom or an alkyl group, an alkylthioalkyl group or an unsubstituted or substituted phenyl group; and R<1> represents an alkyl group, an unsubstituted or substituted benzyl group, a phenethyl group, a phenoxymethyl group, a 2-thienylmethyl group, an alkoxymethyl group or an alkylthiomethyl group; or a salt of said cyclohexane compound (I), which comprises the consecutive steps of cyclizing an acetonylsuccinic acid di-alkyl ester by reaction with a basic reagent ; reacting the resulting compound with an acyl chloride R<1>-CO-Cl ; subjecting the resulting compound to a rearrangement reaction in the presence of a catalyst so as to obtain a compound of formula I ; and optionally converting said compound I into a salt thereof. Said process can be carried out in a single reaction vessel without isolation and purification of the intermediate compounds.