| 摘要 |
PURPOSE: To obtain a composition for increasing a serotonergic function, comprising a 2,3-dihydroergoline compound, a diluent and a carrier, having an action for increasing the endogenous serotonergic function, and useful for an antidepressant therapy, etc. CONSTITUTION: This composition comprises a therapeutically effective amount of a compound of the formula (R is methyl, hydroxymethyl, methylene, etc.; R<1> is methyl, ethyl, n-propyl) [e.g. (3β)-2,3-dihydroxylysergine] or its salt, one or more of diluents and a carrier. The therapeutically effective amount is usually 0.001-50mg/kg body/day. For the medicine composition for parenteral administration, water and a water-miscible organic solvent (e.g. sesame oil or peanut oil) are used. A pharmaceutically permissible diluent, a carrier, an excipient, a lubricant, etc., (e.g. glucose, lactose are also used for the medicine composition for oral administration.
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