| 摘要 |
Thiazolidines (I)[R1, R2=H, alkyl; R3=H, acyl; (un) substd. arom. acyl; R4, R5=H, alkyl, alkoxy; n=1-3; W=CO, CHOR3, Y=O, NH; Z=O, NH , useful as hypolipemics and anticholesteremics, were prepd.. Thus, a mixt. of ester (II)[R1=Me, R2=H, R3=Ac, R4=CMe3, R5=H, W=CO, n=1, X=Cl, A=CO2Et , SC(NH2)2, and sulfolane was heated at 120-130≦̸C for 4hr to give, after treatment with HOCH2CH2OMe, H2O and concd. HCl at 70-90≦̸C for 2.5hr, (I)[R1=Me, R2=R3=R5=H, R4=Me3C, W=CO, n=1, Y=Z=O .
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