发明名称 |
POLYPEPTIDES WITH FIBRONECTIN ACTIVITY |
摘要 |
A composition which can bind heparin and promote cellular adhesion and neurite outgrowth is provided which consists essentially of a polypeptide of the formula: tyr-glu-lys-pro-gly-ser-pro-pro-arg-glu-val-val-pro-arg-pro-arg-pro-gly-val, lys-asn-asn-gln-lys-ser-glu-pro-leu-ile-gly-arg-lys-lys-thr-asp-glu-leu, lys-asn-asn-gln-lys-ser-glu-pro-leu-ile-gly-arg-lys-lys-thr, leu-ile-gly-arg-lys-lys-thr, tyr-arg-val-arg-val-thr-pro-lys-glu-lys-thr-gly-pro-met-lys-glu, ser-pro-pro-arg-arg-ala-arg-val-thr, trp-gln-pro-pro-arg-ala-arg-ile, or mixtures thereof. Medical devices such as prosthetic implants, percutaneous devices and cell culture substrates coated with the polypeptide composition are also provided. |
申请公布号 |
WO8901942(A1) |
申请公布日期 |
1989.03.09 |
申请号 |
WO1988US02913 |
申请日期 |
1988.08.24 |
申请人 |
REGENTS OF THE UNIVERSITY OF MINNESOTA |
发明人 |
FURCHT, LEO, T.;MCCARTHY, JAMES, B. |
分类号 |
A61L15/16;A61F2/06;A61F2/16;A61F2/24;A61F2/32;A61K38/00;A61L27/00;A61L27/22;A61L27/28;A61P43/00;C07K7/06;C07K7/08;C07K14/47;C07K14/78;C12N5/00 |
主分类号 |
A61L15/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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