Galenical forms of theophylline for perlingual and sublingual administration.

摘要

Theophylline is contained in strictly controlled and reproducible amounts in solid vehicles contrived for a gradual release of the active principle per- and sublingually. The process for preparing the new pharmaceutical dosage forms of theophylline entails the following steps: - dissolution of theophylline in a polar solvent to obtain a stock solution: - preparation of dilutions at different concentrations; - fractionation of each of these dilutions into subdilutions; - impregnation by multi-impregnation or fractional impregnation of a pharmaceutically acceptable solid vehicle with each of the subdilutions, each of the abovementioned impregnation steps being followed by a forced-air drying with moisture-free air at a temperature not exceeding 30 DEG C; - protective final impregnation of the sugar-coating type. The solid vehicle can also be a gel prepared from an aqueous solution of theophylline or of one of its soluble salts.