发明名称 |
PROCESS FOR PREPARING 4'-HALOANTHRACYCLINE GLYCOSIDES |
摘要 |
<p>// A process for preparing 4'-halo-anthracycline glycosides having general formula A : A in which X=H or OH, R1=H, OH or OCH3, R2=Br, Cl or F useful as antitumour agents. Those in which X=H may be prepared by an exchange reaction between a 4'-epi-4'-O-trifluoromethanesulphonyl-N-protected-daunorubicin (or a corresponding 4-demethyl or 4-demethoxy derivative) and (C4H9)4NCl, (C4H9)4NBr or C5F. Those in which X=OH are prepared from those in which X=H by bromination and reaction with aqueous sodium formate.</p> |
申请公布号 |
CA1250833(A) |
申请公布日期 |
1989.03.07 |
申请号 |
CA19840460796 |
申请日期 |
1984.08.10 |
申请人 |
FARMITALIA CARLO ERBA S.P.A. |
发明人 |
SUARATO, ANTONINO;PENCO, SERGIO;GIULIANI, FERNANDO;ARCAMONE, FEDERICO |
分类号 |
A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61P35/00;C07H15/252;(IPC1-7):C07H15/252 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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