| 摘要 |
<p>Cephalosporins (I)[R=FCH3, F2CH; R1=R3O-substd.-alkyl; R3=H, OH- protective gp.; R2=H, light metal atom, CO2H-protective gp.! were prepd. Thus, (II) was acylated with F2CHSCH2COC1 and treated with Na 1-(2-hydroxyethyl)tetrazole-5-thiolate to give (I)(R=FCH3, R1=CH2CH2OH, R2=CHPh2) which was hydrolyzed to the acid and treated with NaHCO3 to give (I)(R=FCH3, B2=Na, R1=CH2CH2OH). The salt had a min. inhibiting concn. against E. coli of < 0.1μg/ml.</p> |
