| 摘要 |
Title compds. (I)[R1, R4, R=H, alkyl, alkoxy, OH, allyl; R2= alkoxy, allylmethoxy, (un)substd. amino, mercapto, alkylthio, alkylsulfinyl, alkylsulfonyl, allylthio, allylsulfinyl, allylsulfonyl; R3=(A) or (B) ; X=O, S(O)q; q=0-2!, useful as antiallergics, were prepd. Thus, a mixt. of 6-methoxy-3-(1methyle-thoxy)-benzo[b thiophene-2-carboxylic acid and 1,1'-carbonyldiimidazole in acetonitrile was refluxed with stirring under N2 atmosphere. Triethylamine and 5-aminotetrazole in acetonitrile was added to the reaction mixt.. The mixt. was refluxed for 21.5hr and the residue was acidified with AcOH to give 6-methoxy- 3-(1-methylethoxy-N-1H-tetrazol-5-yl)-benzo[b thiophene-2- carboxamide.
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