| 摘要 |
The derivs. of formula (I), in which R1 and R2 are H, halogen, nitro, amino, 2-5C acylamino, 1-4C alkyl, alkoxy, alkylthio, or alkylsulphonyl, heterocyclylamino, opt. substd. phenyl, phenylthio, phenylsulphonyl or phenylsulphonamido, or together form a 3-5C alkylene link, R3 is 1-4C alkyl or 2-4C alkenyl, R4 is 1-4C alkyl, 2-4C alkenyl or benzyl, and n is 1, 2 or 3, for action on the central nervous system to block the dopamine post-synaptic receptors and for treatment of emesis, depression, anxiety, schizophrenia and acute mania, are made by reacting a cpd. (II) with an amine of formula (R4)2N(CH2)nNH2.
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