FOERFARANDE FOER FRAMSTAELLNING AV TERAPEUTISKT AKTIVA 6(R)-/2-(8-ACYLOXI-2,6-DIMETYLPOLYHYDRONAFTYL-1)- ETYL/-4(R)-HYDROXI-3,4,5,6-TETRAHYDRO-2H-PYRANONER OCH 7-/8-ACYLOXI- 2,6-DIMETYLPOLYHYDRONAFTYL-1/-3(R),5(R)-DIHYDROXIHEPTANSYROR.

摘要

6(R)-[2-(8 min -acyloxy-2 min -methyl-6 min -methyl (or hydrogen)polyhydronaphthyl-1 min )-ethyl]-4(R) -hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones are prepared by acylation of the corresponding 8 min -hydroxy compounds. The products are strong inhibitors of the biosynthesis of cholesterol. The 8 min -hydroxy compounds are prepared by hydrolysis of the corresponding, naturally occurring 8 min -(2(S)-methylbutyryloxy) compounds with a strong base at elevated temperatures to remove the acyl group.