6-Alkylidene 10 beta -alkynylestrene derivatives and pharmaceutical methods for their use

摘要

The invention relates to 6-substituted 10 beta -alkynylestrene derivatives wherein the 6 substituent is amino, azido, halogen or an alkylidene group and to corresponding 6,7-dihalo analogs. The invention provides also a process for the preparation of the above compounds and pharmaceutical compositions containing same. The compounds of the invention are useful aromatase inhibitors and can be used, e.g., in the treatment of hormone-dependent tumors and prostatic hyperplasia.