发明名称 |
PROCESS FOR PRODUCTION OF TETRASOLE-DERIVATIVES DECREASING THE PATHALOGICALLY HIGH COLESTHERIN-LEVEL OF BLOOD AND INTERMEDIERS APPLICABLE FOR THEIR PRODUCTION |
摘要 |
This invention provides novel tetrazole intermediates of the formula <IMAGE> wherein R1 and R4 each are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy or trifluoromethyl; R2,R3,R5 and R6 each are independently hydrogen, halogen, C1-4 alkyl or C1-4 alkoxy; B is hydrogen, C1-4 alkoxycarbonyl, CH2Y or CH2Z; Y is hydrogen, hydroxyl or X; Z is <IMAGE> X is bromo, chloro or iodo; R10 is C1-4 alkyl; and R11 is phenyl which is unsubstituted or substituted by one or two C1-4 alkyl or chloro substituents. and processes thereof which are useful for the preparation of antihypercholesterolemic agents. |
申请公布号 |
HUT47258(A) |
申请公布日期 |
1989.02.28 |
申请号 |
HU19880000885 |
申请日期 |
1988.02.24 |
申请人 |
BRISTOL-MYERS CO,US |
发明人 |
WRIGHT,JOHN J.,US;SIT,SING-YUEN,US;BALASUBRAMANIAN,NEELAKANTAN,US;BROWN,PETER J.,US |
分类号 |
A61K31/41;A61P3/06;C02F11/00;C07D257/04;C07D405/06;C07F9/6524 |
主分类号 |
A61K31/41 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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