发明名称 |
Trans-6-[2-(N-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl]- or ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
摘要 |
Certain trans-6-[2-(_N-heteroaryl-3,5-disubstituted)pyrazol-4-yl)ethyl]- or ethenyl]tetrahydro-4-hydroxy-2_H-pyran-2-ones and the corresponding ring-opened acids derived therefrom which are potent inhibitors of the enzyme 3-hydroxy-3-methylglutarylcoenzyme A reductase (HMG CoA reductase) and are thus useful hypolipidemic or hypocholesterolemic agents. Pharmaceutical compositions containing such compounds, and a method of inhibiting the biosynthesis of cholesterol employing such pharmaceutical compositions are also disclosed.
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申请公布号 |
US4808621(A) |
申请公布日期 |
1989.02.28 |
申请号 |
US19870048473 |
申请日期 |
1987.05.18 |
申请人 |
WARNER-LAMBERT COMPANY |
发明人 |
ROTH, BRUCE D.;SLISKOVIC, DRAGO R. |
分类号 |
A61K31/415;A61K31/44;A61K31/443;A61K31/4433;A61K31/47;A61K31/505;A61P3/06;A61P43/00;C07D405/14;C07D409/14;C07D417/14;(IPC1-7):C07D405/04;C07D405/06 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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