VESSEL WITH SKIMMER PROCESS FOR PRODUCING LITTLE PARTICLES OF PHARMACEUTICAL ACTIVE MATERIALS

摘要

The present invention is concerned with the simultaneous formation and encapsulation of small particles of organic compounds whose solubility in water is greater at a first pH than at a second pH by concurrently precipitating said organic compounds as small particles and forming a coacervate of an anionic (or cationic) surfactant and an amphoteric surfactant. The process is preferably used to prepare a readily soluble encapsulated pharmaceutically active compound.