Bromocriptine compsns. for oral admin - with controlled release properties, useful for treating Parkinson's disease, hyper-prolactinaemia etc.

摘要

Pharmaceutical compsns. for controlled release of bromocriptine (I) on oral admin. release less than 50 wt.% (I) in 2.5 hr, as measured in 0.1N HCl in vitro. The compsns. comprise (I), a swellable hydrophilic substance (II) and a fatty material (III). The compsns. are formulated as powders for use in capsules, the unit dose being 2-20 (esp. 5-10) mg (I). The (I):(II) wt. ratio is 1:10-35 (esp. 1:16-25) and the (I):(III) wt. ratio is 1:1-10 (esp. 1:6-10). (II) is a cellulose deriv., esp. hydroxypropyl methylcellulose (HPMC) or Na carboxymethyl cellulose. (III) is a fatty acid glyceride or ester with a m.pt. of 45-65 deg.C. The compsns. may also contain other additives, e.g. fillers. USE - (I) is a dopamine against.