NOVEL 1,5-BENZOTHIAZEPINE DERIVATIVE, PROCESSES FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS

摘要

Novel 1,5-benzothiazepine derivatives of the formula: (I) wherein R1 and R4 are: (a) R1 is lower alkyl or lower alkoxy, and R4 is lower alkyl, lower alkoxy, fluorine, benzyloxy, hydroxy or lower alkylthio, or (b) R1 is lower alkyl, and R4 is hydrogen, or (c) R1 is hydroxy, and R4 is lower alkyl, fluorine, hydroxy or lower alkylthio; R2 is hydrogen, lower alkanoyl or benzoyl; and R3 is lower alkyl; and a pharmaceutically acceptable acid addition salt thereof are disclosed. Said derivative (I) and its salt have a potent platelet aggregation-inhibiting activity.