发明名称 |
Cephalosporins, processes for their preparation and pharmaceutical compositions containing them. |
摘要 |
<p>Cephalosporin derivatives having a 3-position substituent of the formula I are described: <CHEM> wherein R<1> is hydrogen, alkenyl or optionally substituted alkyl, Het is a 5- or 6-membered heterocyclic ring bonded via a carbon atom to the amide linkage, wherein Het is selected from a group of the formulae II - III: <CHEM> wherein A is CH or a nitrogen atom; B is oxygen, sulphur or a group NR<4>; one or two of D, E, F and G are nitrogen atoms and the remainder are CH groups: or Het is a pyrazinone, pyridinone, pyridazinone or pyrimidinone ring, or is a thione equivalent of such a ring, said rings having a substituent R<4> on one nitrogen atom, or is pyranone, or pyranthione; the ring Het being fused by any two adjacent carbon atoms to the benzene ring; and Het being attached to the -CH2NR<1>CO- group via a carbon atom; R<2> is hydroxy or an in vivo hydrolysable ester thereof; R<3> is ortho to R<2> and is hydroxy or an in vivo hydrolysable ester thereof; and R<4> has various values. The use of such compounds as antibacterial agents is described as are processes for their preparation and intermediates therefor.</p> |
申请公布号 |
EP0304158(A1) |
申请公布日期 |
1989.02.22 |
申请号 |
EP19880306420 |
申请日期 |
1988.07.13 |
申请人 |
IMPERIAL CHEMICAL INDUSTRIES PLC;ICI PHARMA |
发明人 |
ARNOULD, JEAN CLAUDE;JUNG, FREDERICK HENRI;BOUCHEROT, DOMINIQUE;STRAWSON, COLIN JOHN;DAVIES, DAVID HUW |
分类号 |
A61K31/546;A61K31/545;A61P31/04;C07D;C07D209/04;C07D209/42;C07D215/22;C07D215/48;C07D215/54;C07D217/26;C07D215/56;C07D217/22;C07D237/28;C07D239/28;C07D239/72;C07D239/74;C07D239/80;C07D239/88;C07D239/90;C07D241/00;C07D241/44;C07D251/54;C07D311/04;C07D311/08;C07D311/18;C07D311/22;C07D311/76;C07D471/00;C07D501/00;C07D501/04;C07D501/24;C07D501/38;C07D501/40;C07D501/46;C07D501/48;C07D501/56;C07D501/57;(IPC1-7):C07D501/46 |
主分类号 |
A61K31/546 |
代理机构 |
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代理人 |
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地址 |
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