| 摘要 |
PURPOSE: To obtain an implantable delivery system capable of releasing an LHRH resembling compound at a constant rate over a long period of time by incorporating and dispersing a water soluble particle phase containing the LHRH resembling compound in a prescribed amount in a silicone elastomer matrix. CONSTITUTION: This administration controlling delivery preparation is obtained by dispersing and incorporating water soluble particles (preferably lumps having 1-500μm diameter consisting of primary particles having 0.1-1μm diameter) containing a LHRH(luteinzing hormone releasing hormone) resembling compound or medicinally permissible salts thereof in a silicone elastomer such as a polydimethylsiloxane polymer is 30-42wt.% ratio. As the LHRH resembling compound, a compound of formula I [V is triptophyl, phenylalanyl, etc.; W is tyrosyl, phenylalanyl, etc.; X is formula II (R is phenyl, naphthyl, a perhydrobiphenylyl, etc.); Y is leusyl, isoleusyl, etc.; Z is glycinamide, NHR1 (R1 is an alkyl, a cycloalkyl, etc.)] is preferable.
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