| 摘要 |
A compound of formula (I), or a pharmaceutically acceptable salt thereof, <CHEM> in which, R1 is hydrogen, lower alkyl or CH2OR6; R2 is hydrogen or lower alkyl; R3 is hydrogen or lower alkyl; each of W and Z, which are different, represents -CR4R5- or -(CRxRy)n-, in which, R4 is hydrogen, C1-3 alkyl, C1-3 alkylthio or C1-3 alkoxy; R5 is C1-3 alkyl, C1-3 alkylthio or C1-3 alkoxy; or together R4 and R5 form a 3 to 6 membered carbocyclic ring, or a heterocyclic ring containing one or two ring oxygen, nitrogen or sulphur atoms; or R4 and R5 together form an oxo or methylene group; each of Rx and Ry is hydrogen or C1-3 alkyl; n is zero or 1; R6 is hydrogen, lower alkyl, lower alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, heteroarylcarbonyl, optionally substituted aminocarbonyl, lower alkoxycarbonyl and aryloxycarbonyl; R7 is hydrogen or lower alkyl; X is oxygen or sulphur; and A is sulphur, oxygen or -NH-, is useful for the treatment of heart disease. |
