Kynurenic acid derivatives useful in the treatment of neurodegenerative disorders.

摘要

4-Oxo-1,4-dihydroquinoline compounds having a 2-acidic group or a group convertible thereto in vivo, and their pharmaceutically acceptable salts, are potent specific antagonists of N-methyl-D-aspartate (NMDA) receptors and are therefore useful in the treatment of neurodegenerative disorders. 4-Oxo-1,4-dihydroquinoline compounds having a 2-acidic group or a group convertible thereto in vivo, other than carboxy or C1-6 alkoxycarbonyl, are novel compounds, as also are compounds of formula II <CHEM> wherein R<2> represents carboxy or a group convertible thereto in vivo, R<6> is hydrogen and R<5> and R<7> represent C1-6 alkyl or halogen, provided that R<5> and R<7> are not simultaneously chlorine or simultaneously bromine; a process for preparing the novel compounds is described, as also are pharmaceutical compositions containing the novel compounds.