发明名称 |
Optical isomers of a spiroquinuclidine derivative. |
摘要 |
<p>The (+)-cis-, (-)-cis-, (+)-trans- and (-)-trans- forms of 2-methylspiro(1,3-oxathiolan-5,3 min )quinuclidine <CHEM> are prepared by optical resolution of each of the (+/-)-cis- and (+/-)-trans-isomers. These compounds find application in treating diseases of the central nervous system in mammals, especially diseases due to a deficiency in the central cholinergic system. Biological tests indicate that the (-)-cis-form, as well as the (+/-)-cis-isomer, shows particular promise for treating senile dementia of Alzheimer's type.</p> |
申请公布号 |
EP0303391(A2) |
申请公布日期 |
1989.02.15 |
申请号 |
EP19880307162 |
申请日期 |
1988.08.03 |
申请人 |
STATE OF ISRAEL REPRESENTED BY THE PRIME MINISTER'S OFFICE THE ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH |
发明人 |
FISHER, ABRAHAM;KARTON, ISHAI |
分类号 |
A61K31/435;A61P25/28;C07D497/20;(IPC1-7):C07D497/20 |
主分类号 |
A61K31/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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