| 摘要 |
<p>Delta-opioid receptor antagonists are disclosed of formula (I) or (II), wherein R1 is (C¿1?-C5)alkyl, C3-C6(cycloalkyl)alkyl, C5-C7(cycloalkenyl)alkyl, aryl, aralkyl, trans-(C4-C5)alkenyl, allyl or furan-2-ylalkyl, R?2¿ is H, OH or O¿2?CR, wherein R is (C1-C5)alkyl; R?3¿ is H, (C¿1?-C5)alkyl or RCO; X is O, S or NY, wherein Y is H or (C1-C5)alkyl; M is N or CH; and R?4 and R5¿ are individually H, F, Cl, Br, NO¿2?, NH2, (C1-C5)alkyl or (C1-C5)alkoxy or R?4 and R5¿ together are benzo; and the pharmaceutically acceptable salts thereof.</p> |
