| 摘要 |
PURPOSE: To repair a bone defect by using a composition having an extending agent containing reconstructed atelopeptide collagen of fibril in addition to spontaneous marrow. CONSTITUTION: A composition used for repairing a bone defect contains, as active components, an aqueous suspension containing 10-100mg/ml of reconstituted fibril atelopeptide refined collagen, and spontaneous marrow. The injectable collagen suspension is contained in an amount of 50-95vol.% of the composition. The collagen part is formed of a nonimmunogen type reconstituted fibril preparation, and the collagen preparation is prepared from the skin of animals. The solution-like collagen is reconstituted to a fibril state by neutralizing this solution at a low temperature, about 10-25 deg.C, preferably under a low osmotic pressure related to physiological ion intensity, and the final pH is preferably within a range of 7-8. By the property of the reconstituted fibril of such a collagen preparation, the bone growth conduction induced by the marrow in the composition can be performed. |
