Anti-emetic serotonin depleting agents.

摘要

Compounds of the formula: <CHEM> wherein, R is selected from hydrogen, loweralkyl, trifluoromethyl, carboxyl, or loweralkoxycarbonyl; R1 and R2 are hydrogen or loweralkyl; Z is trifluoromethyl or halogen; the optical isomers and pharmaceutically acceptable salts thereof are active as antiemetics. Two of the preferred compounds are fenfluramine and norfenfluramine.