5H-(1)BENZOPYRANO (2,3-D) PYRIMIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND THEIR USE IN CONTROLLING LESIONS OF GASTRIC AND DUODENAL MUCOUS MEMBRANES

摘要

S u m m a r y The invention relates to 5H-¢1!-benzopyrano-¢2,3-d!pyrimi-dine derivatives of the general formula I (I), wherein R1 and R2, which may be the same or different, represent a hydrogen or halogen atom, a hydroxyl group or a straight-chain or branched alkoxy group with up to four carbon atoms, or together form an alkylenoxy- or alkylendioxygroup with 1 to 3 carbon atoms or represent a condensed aromatic ring, R3 represents an optionally substituted phenyl radical, R4 an alkyl group containing 1 to 8 carbon atoms or the radical wherein R5 and R6, which may be the same or different, represent a hydrogen atom, a straight-chain or branched alkyl group with up to 6 carbon atoms or together with the nitrogen atom to which they are attached form a saturated 5- or 6 membered ring optionally containing further heteroatoms and n represents the figures 2 to 6, and their pharmacologically acceptable salts with organic or anorganic acids. The compounds according to formula I may be prepared by means of a new chemical process and have a protective effect similar to that of Cimetidine, but do not exhibit the undesired side effects of antisecretory agents. The invention is based on a new mucoprotective mode of action which prevents that lesions of the mucous membrane epithelium arise.