| 摘要 |
Tylosin derivatives shown by the general formula <IMAGE> wherein R represents a hydrogen atom or a hydroxyl group; R1 represents a halogen atom, a hydroxyl group, a tetrahydrofuranyloxy group, a tetrahydropyranyloxy group, a tetrahydrothiofuranyloxy group, a tetrahydrothiopyranyloxy group, an alkanoyloxy group, an arylcarbonyloxy group, an aralkylcarbonyloxy group, a lower alkylthiomethyloxy group, a heterocyclic thio group which may have a substituent, a mono- or di- lower alkylamino lower alkylthio group or a group of <IMAGE> (wherein R4 represents a hydroxyl group or an alkanoyloxy group); R2 represents a hydrogen atom, a hydroxyl group, or an alkanoyloxy group; R3 represents a hydroxyl group or an alkanoyloxy group; and represents a single bond or a double bond, but represents a double bond when R2 is a hydrogen atom. These compounds are useful as antibiotics.
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