| 发明名称 |
DNA constructs containing a Kluyveromyces alpha-factor leader sequence for directing secretion of heterologous derivatives. |
| 摘要 |
<p>DNA constructs that are useful for providing secretory expression of heterologous polypeptides in yeast comprising a DNA sequence that includes a Kluyveromyces alpha -factor leader sequence linked to the heterologous polypeptide by a yeast processing signal. Constructs employing the K. lactis alpha -factor leader and processing signal sequences, with and without spacer, linked to prochymosin are exemplified.</p> |
| 申请公布号 |
EP0301669(A1) |
申请公布日期 |
1989.02.01 |
| 申请号 |
EP19880201631 |
申请日期 |
1988.07.28 |
| 申请人 |
GIST-BROCADES N.V.;CHIRON CORPORATION |
发明人 |
VAN DEN BERG, JOHANNES A., DR.;BRAKE, ANTHONY J., DR. |
| 分类号 |
C07H21/04;C07K14/39;C12N9/64;C12N15/00;C12N15/09;C12N15/81;C12P21/00;C12P21/02;C12R1/645;(IPC1-7):C12N15/00 |
主分类号 |
C07H21/04 |
| 代理机构 |
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代理人 |
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