发明名称 Highly stable hybridomaoma cell line for antibody prodn. - made by fusing secreting cell with compatible xenogeneic hybrid as immortalising component
摘要 Hybridoma cell line consists of (1), as immortalised cell component, a xenogenetic Hybridoma which has lost (or lacks) ability to produce a particular material, fused to (2) a cell which is able to produce a specific cpd. (A). Component (2) is genetically compatible with the non-transformed partner in the xenogenetic hibridoma. Component (2) and the non-transformed partner in (1) are from the same species, esp. human. (2) is particularly a lymphocyte which has been pre-sensitised to produce (A). USE/ADVANTAGE - When (1) is used as immortalising component, the final hybridomas have higher stability, provide higher (A) yields; grow rapidly and are easy to clone.
申请公布号 CH668775(A5) 申请公布日期 1989.01.31
申请号 CH19830003773 申请日期 1983.07.08
申请人 SANDOZ AG 发明人 OESTBERG, GUNNAR LARS, DR.
分类号 C07K16/00;C07K16/12;C12N5/26;(IPC1-7):C12N5/00;C12N15/00 主分类号 C07K16/00
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