发明名称 |
Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
摘要 |
The invention offers an early detection method for atherosclerosis using genetic analysis to detect a polymorphisms shown to be correlated with this disease which are proximal to the apolipoprotein AI (apoAI) and aplipoprotein CIII (apoCIII) gene complex. All individuals with a 300 bp deletion 4 kb upstream of the apoAI gene are destined to experience severe atherosclerotic symptomologies. Individuals with a polymorphism 5.4 kb 5' of the apoAI gene or a PvuII polymorphism in the first intron of the apoCIII gene also seem to be at greater risk. A haplotype with MspI and XmnI/7.2 polymorphisms in this general region seem to be protected. Additional polymorphic sites in the DNA sequence associated with the apoAI/CIII gene complex provide a means for genetically fingerprinting individuals, and for identifying persons at risk with respect to disorders relating to lipid metabolism and transport.
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申请公布号 |
US4801531(A) |
申请公布日期 |
1989.01.31 |
申请号 |
US19850782666 |
申请日期 |
1985.09.30 |
申请人 |
BIOTECHNOLOGY RESEARCH PARTNERS, LTD. |
发明人 |
FROSSARD, PHILIPPE M. |
分类号 |
C12Q1/68;(IPC1-7):C12Q1/68;G01N33/567 |
主分类号 |
C12Q1/68 |
代理机构 |
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