发明名称 Fibrinolytic composition
摘要 In accordance with the present invention, a composition is provided that is effective in dissolving blood clots and reestablishing and maintaining blood flow through thrombosed coronary or other blood vessels. The fibrinolytic composition of the present invention comprises an enzyme, such as streptokinase, urokinase, tissue plasminogen activator or other fibrinolytic enzyme, and a surface-active copolymer. The surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C2H4O)b(C3H6O)a(C2H4O)bH wherein a is an integer such that the hydrophobe represented by (C3H6O) has a molecular weight of approximately 950 to 4000, preferably approximately 1750 to 3500, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 50% to 90% by weight of the compound.
申请公布号 US4801452(A) 申请公布日期 1989.01.31
申请号 US19870045459 申请日期 1987.05.07
申请人 HUNTER, ROBERT L.;DUNCAN, ALEXANDER 发明人 HUNTER, ROBERT L.;DUNCAN, ALEXANDER
分类号 A01N1/02;A61K31/765;A61K38/16;A61K38/44;A61K38/49;(IPC1-7):A61K37/54;A61K37/547;A61K37/50 主分类号 A01N1/02
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