发明名称 |
5-lipoxygenase inhibitors |
摘要 |
This invention encompasses compounds and methods for inhibiting lipoxygenase and includes a pharmaceutical composition comprising a pharmaceutical carrier and an effective lipoxygenase inhibiting amount of a compound of the formula: <IMAGE> wherein R1 and R2 are the same or different members of the group consisting of tert-alkyl of 4 to 10 carbon atoms; and R3 is <IMAGE> (a) wherein R4 is hydrogen or lower alkyl; <IMAGE> (b) <IMAGE> (c) wherein R6 and R7 may be the same or different and are alkyl of 1 to 4 carbon atoms; or <IMAGE> (d) and the pharmaceuticlaly acceptable salts thereof. The compounds and pharmaceutical formulations of the present invention are 5-lipoxygenase inhibitors and, therefore, are useful in the treatment of local and systemic inflammation, allergy and hypersensitivity reactions and other disorders in which agents formed in the 5-lipoxygenase metabolic pathway are involved.
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申请公布号 |
US4801611(A) |
申请公布日期 |
1989.01.31 |
申请号 |
US19870047237 |
申请日期 |
1987.05.07 |
申请人 |
G. D. SEARLE & CO. |
发明人 |
CHINN, LELAND J.;DESAI, BIPINCHANDRA N.;MUELLER, RICHARD A. |
分类号 |
A61K31/10;A61K31/19;A61K31/215;A61K31/335;A61K31/365 |
主分类号 |
A61K31/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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