| 摘要 |
<p>PURPOSE:To obtain the titled compound useful as medicines, agricultural chemicals, etc., such as metabolic antagonistic substance, RNA synthesis inhibitor, antitumor agent or antiviral agent, by converting a specific group in a deoxy-fluoropentofuranoside derivative into H atom. CONSTITUTION:The -OX group in a 3-deoxy-3-fluoropentofuranoside derivative expressed by formula I [R<1> is halogen, -OZ (Z is alkyl or OH-protecting group) or residue of nucleic acid bases which may have a protecting group; R<2> is OH- protecting group; X is H or eliminative activating group] is converted into H atom to afford the aimed compound expressed by formula II. Furthermore, the -OX group is preferably converted into the H atom by using a reducing agent, such as tributyltin hydride or triphenyltin hydride.</p> |
