PROCEDEU DE OBTINERE A SARII DISODICE A CARBENICILINEI

摘要

The process of general formula (I) through treatment of a 30% phenyl malonic acid suspension in benzene with 30% solution of PCl5 in benzene at 75-80 degrees C at a volumetric ratio with distillation of the benzene and the POCl3, gives acid ketone chloride, the solution of which is used to treat salts of sodium based on 6-aminopenicillanic acid in acetone with water and bicarbonate of soda. to increase product yield and purity, nitrogen is injected into the reaction mixture, and butyl acetate and butanol are used as washing solvents.