| 摘要 |
<p>This invention presents novel 2-azetidinone compounds of formula (I), wherein R1 and R2 are the same or different and are hydrogen, (C1-C12) alkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, (C3-C10) cycloalkyl, phenyl optionally substituted with from one to 3 substituents selected from the group consisting of halogen, hydroxy, amino, nitro, (C1-C4)alkyl, and (C1-C4)alkoxy, benzyl optionally substituted with from one to 3 substituents selected from the group consisting of halogen, hydroxy, amino, nitro, (C1-C4)alkyl, and (C1-C4)alkoxy, -CH2-O-CO-CH2-NHR4, -CH2-O-CO2-R5, -CH2F, or -CHF2; wherein R4 is hydrogen, -CHO or -CO-O-C(CH3)3; wherein R5 is -(C1-C8)alkyl, -(CH2)2NH-CO-O-C(CH3)3, -(CH2)2N(CH3)-CO-O-C(CH3)3, -(CH2)2OC(O)NH2, -(CH2)2Cl, -(CH2)2OCH3 or -(CH2)2NHCHO; wherein R3 is an acyl group derived from a carboxylic acid; wherein R6 is hydrogen or methyl; wherein R7 is hydrogen or methyl; wherein R11 is hydroxy or -O-CH2(C6H5); with the proviso that both R6 and R7 cannot be methyl. These compounds have an activating group which contains a chiral pyrazolidinone moiety and are useful as antibacterial agents.</p> |
