| 摘要 |
<p>NEW MATERIAL:A compound expressed by formula I (R1 and R2 are H or 2-4C alkyl; A is amino, monoalkylamino, dialkylamino, nitrogen-containing saturated 3--6-membered heterocyclic ring which may optionally contain addi tional atoms of O, S or N; n is 1-12, but 7-12 only when A is amino, mono- or dialkylamino) and salt thereof. EXAMPLE:2-[N-1(S)-Carboxy-8-aminooctyl]-L-alanyl]-1,2,3,4-tetrahydrois oquinoli ne-3(S)-carboxylic acid. USE:A remedy for hypertension. PREPARATION:A compound expressed by formula II (X is Cl, Br, I or alkylsulfonyloxy) is reacted with a compound expressed by formula III to pro vide a condensation produce in a protected form. The protecting group is then removed.</p> |
