PREPARATION OF UNILAMELLAR LARGE DIAMETER LIPOSOMES, THEIR PHARMACEUTICAL APPLICATION IN VIEW OF THE ENCAPSULATION OF THE ACTIVE PRINCIPLE FOR SUSTAINED RELEASE, AND DEVICE THEREFOR

摘要

PCT No. PCT/FR84/00221 Sec. 371 Date Jun. 6, 1985 Sec. 102(e) Date Jun. 6, 1985 PCT Filed Oct. 5, 1984 PCT Pub. No. WO85/01440 PCT Pub. Date Apr. 11, 1985.A device for obtaining unilamellar liposomes comprising means for forming a solution of lipids, a detergent (octylglucoside) and a pharmaceutically active substance; means for taking an aliquot quantity of said solution; permeable and/or semipermeable membrane partitions for eliminating said detergent by dialysis with polymers in the form of beads; and means for administering to patients the resulting solution free of detergent.