| 摘要 |
<p>Novel chromone-8-aldehydes and thiochromone-8-aldehydes, useful in making pharmaceutically active dihydropyridines, of the formula in which R1 represents hydrogen, a C1-10 aliphatic hydrocarbon radical, a C1-C10 alkyl carboxylate, or an aromatic or heteroaromatic ring which optionally has 1-5 identical or different halogen C1-C10-alkyl, C1-C10-alkoxy, C1-C10-alkylthio, C1-C10-alkylsulphinyl, cyano, hydroxyl, nitro, C1-C5-monofluoroalkyl or polyfluoroalkyl, C1-C5 monofluoroalkoxy or polyfLuoroalkoxy, C1-C6 monofluoroalkylthio or polyfluoroalkylthio, amino, C1-C5-monoalkyl-amino or C1-C5 dialkylamino substituents, R2 represents hydrogen or 1 to 3 halogen atoms, A represents a single bond, a C1-C20 alkylene chain or a C2-C20 alkenylene chain which can optionally be interrupted by oxygen or sulphur, and X represents oxygen or sulphur, are made from corresponding compounds which in 8-position carry an ester or olefinic radical.</p> |
