| 摘要 |
PCT No. PCT/JP85/00548 Sec. 371 Date Jun. 3, 1986 Sec. 102(e) Date Jun. 3, 1986 PCT Filed Oct. 3, 1985 PCT Pub. No. WO86/02074 PCT Pub. Date Apr. 10, 1986.A novel 1,4-thiazine derivative represented by the formula I, a pharmaceutically acceptable acid addition salt thereof, a process for preparation thereof and a cardiotonic agent comprising it as an effective component; <IMAGE> I wherein R1 and R2 represent respectively hydrogen atom, lower alkyl group, lower alkoxy group, amino group, lower alkyl-amino group, aryl-amino group, hydroxy group, aryl group or 5- or 6-membered heterocyclic residue; R3 and R4 represent hydrogen atom or lower alkyl group; and R5 represents N-containing heterocyclic residue and is not pyridinyl group when R1 and R2 represent hydrogen atom and R3 and R4 represent hydrogen atom or lower alkyl group.
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