| 摘要 |
<p>1. Process for the preparation of 2-(2-thienyl)- and -(3-thienyl-ethylamines of the formula I : see diagramm : EP0069002,P5,F2 in which R1 and R2 , which may be the same or different, represent each a hydrogen atom, a straight- or branched-chain alkyl radical, a heterocyclic or non-heterocyclic aromatic radical, optionally mono- or poly-substituted, comprising catalytically hydrogenating in non alcaline medium in an alcohol or an organic acid or their mixture under a hydrogen pressure of 1 to 100 atmospheres at a temperature of 20 to 100 degrees C, and in the presence of a metal catalyst associated with an inert carrier, a compound of the formula IV : see diagramm : EP0069002,P5,F3 in which R1 and R2 are as defined above, to give a compound of the formula V : see diagramm : EP0069002,P5,F4 in which R1 and R2 are as defined above, isolating compound (V) and then catalytically hydrogenating same in alcaline medium under a hydrogen pressure of 1 to 100 atmospheres, at a temperature of 20 to 100 degrees C, and in the presence of a metal catalyst on a carrier to give a compound of the formula (I).</p> |
