| 摘要 |
NEW MATERIAL:An antibiotic substance methylenolactomycin of formula having the following physical and chemical properties. Melting point, 82.5-83.5 deg.C; specific rotation, [alpha]D<26>=-2.37 deg. (C3.0 CH3OH); molecular formula, C11H16O4; molecular weight, 212; solubility, easily soluble in methanol, acetone, ethyl acetate, ethyl ether, chloroform and benzene, insoluble in n-hexane and water; etc. USE:A medicine. It has antibacterial activity against a certain kind of bacteria, exhibits life-prolonging effect to a mouse affected with Ehrlich ascites carcinoma and has anti-tumor activity. PREPARATION:Penicillium 24-4 strain (FERM P-9437) or Penicillium 43-3 strain (FERM P-9438) is cultured in a liquid medium under shaking or under aeration and agitation for 72-216hr and the objective antibiotic substance, methylenolactomycin of formula, is separated from the cultured product. |
