PHARMACEUTICAL FORMULATION ENSURING THE TRANSDERMAL ABSORPTION OF THE ACTIVE INGREDIENT AND PROCESS FOR PREPARING SAME

摘要

PCT No. PCT/HU88/00044 Sec. 371 Date Feb. 17, 1989 Sec. 102(e) Date Feb. 17, 1989 PCT Filed Jun. 22, 1988 PCT Pub. No. WO88/10111 PCT Pub. Date Dec. 29, 1988.The invention relates to a multilayer pharmaceutical formulation containing layers with various active ingredient content, a water-impermeable layer applied thereon and an adhesive layer ensuring the fixation to the body surface of the pharmaceutical formulation, which comprises: a silicone rubber layer directly contacting with the skin surface and ensuring the zero order kinetics of the dissolution of the active ingredient; as well as a multilaminated silicone rubber matrix comprising one or more layers(s) with various active ingredient content.