摘要 |
The use of an olefinic compound of the formula R<1>R<2>R<3>C-CR<4> = CR<5>R<6> (I), wherein R<1> is a heterocyclyl radical selected from 1,2,4-triazolyl, imidazolyl, 5-(1-6C alkyl)imidazol-1-yl, pyridyl and pyrimidinyl; R<2> and R<3>, which may be the same or different, are each a hydrogen atom or a 1-6C alkyl radical; R<4> is a phenyl or pyridyl radical, optionally bearing one or more substituents selected from halogen atoms, amino, cyano, carbamoyl and nitro radicals, 1-6C alkyl, halogenoalkyl, alkoxy, halogenoalkoxy, alkylamino and alkylcarbamoyl radicals, di(1-6C alkyl)amino, di(1-6C alkyl)carbamoyl and 2-6C alkoxycarbonyl radicals; R<5> is a hydrogen or halogen atom, a 1-6C alkyl radical or a phenyl radical optionally bearing one or more substituents as defined above for R<4>; and R<6> is a phenyl or pyridyl radical optionally bearing one or more substituents as defined above for R<4>; or, for those compounds which contain a basic nitrogen atom, the pharmaceutically or veterinarily acceptable salts thereof, for the manufacture of a pharmaceutical or veterinary composition having utility as an aromatase inhibitor. |